Corticosrone
皮質酮,又稱 17-脫氧皮質醇和 11β,21-二羥基黃體酮,是一種 21 碳的皮質類固醇激素,在腎上腺皮質中產生。除了 17α-羥化酶缺乏導致的非常罕見的 先天性腎上腺增生癥外,它對人類的重要性不大。在許多物種中,包括兩棲 動物、爬行動物、嚙齒動物和鳥類,皮質酮是一種主要的糖皮質激素,參與 調節能量、免疫反應和壓力反應。皮質酮通過醛固酮合成酶轉化為醛固酮, 醛固酮合成酶僅在腎小球細胞的線粒體中發現。腎小球細胞存在于腎小球區, 它是腎上腺皮質內分泌細胞的最表層區域。皮質酮是礦物皮質激素醛固酮的前體分子,是體內鈉和鉀水平的主要平衡調節劑之一。
可檢測樣本中大鼠的CORT,且與其類似物無明顯交叉反應。
由于實驗操作條件的不同( 如操作者、移液技術、洗板技術和穩定條件等),標準曲線的OD值會有所差異。以下數據和曲線僅供參考,實驗者需根據自己的實驗建立標準曲線。
板內變異系數小于10%,板間變異系數小于10%
在選取的健康大鼠血清、血漿和中加入3個不同濃度水平的大鼠CORT,計算回收率
分別在選取的4份健康大鼠血清、血漿和中加入高濃度大鼠CORT,在標準曲線動力學范圍內進行稀釋,評估線性。
注:ELISA試劑盒檢測范圍等數據,因檢測樣本 的不同而調整,實際數據以隨貨說明書為準。
Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring
Rank: IF 6.9
Journal: Biomedicine & Pharmacotherapy
Year: 2019
DOI: 10.1016/j.biopha.2019.109077
Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring
Rank: IF 6.1
Journal: Phytotherapy Research
Year: 2020
DOI: 10.1002/ptr.6692
Ferulic Acid Improves Depressive-Like Behavior in Prenatally-Stressed Offspring Rats via Anti-Inflammatory Activity and HPA Axis
Rank: IF 4.9
Journal: International Journal of Molecular Sciences
DOI: 10.3390/ijms20030493
Tetrandrine inhibits aldosterone synthesis by covalently targeting CYP11A1 to attenuate hypertension
Rank: IF 4.4
Journal: Frontiers in Pharmacology
Year: 2024
DOI: 10.3389/fphar.2024.1387756
Effects of cannabidiol on AMPKα2 /HIF-1α/BNIP3/NIX signaling pathway in skeletal muscle injury
DOI: 10.3389/fphar.2024.1450513
Camellia nitidissima Chi extract promotes adult hippocampal neurogenesis and attenuates chronic corticosterone-induced depressive behaviours through regulating Akt/GSK3β/CREB signaling pathway
Rank: IF 3.8
Journal: Journal of Functional Foods
Year: 2022
DOI: 10.1016/j.jff.2022.105199
Beneficial effects of Dendrobium nobile Lindl. alkaloids (DNLA) on anxiety and depression induced by chronic unpredictable stress in rats.
Rank: IF 2.7
Journal: Brain Research
Year: 2021
DOI: 10.1016/j.brainres.2021.147647
Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis.
Journal: Brain Sciences
DOI: 10.3390/brainsci12050589
Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats: a potential role of the hypothalamic-pituitary-adrenal axis
Rank: IF 2
Journal: Journal of Traditional Chinese Medicine
Year: 2023
DOI: 10.19852/j.cnki.jtcm.20230727.001
Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats
Rank: IF 0.7
Journal: Journal of Traditional Chinese Medical Sciences
DOI: 10.1016/j.jtcms.2022.03.005